The skin barrier is the body’s first line of defense against the external environment and a critical determinant of skin health and physiological homeostasis.
The global standard metric for evaluating skin barrier function is Transepidermal Water Loss (TEWL), which quantitatively measures the amount of water evaporating through the epidermis. TEWL is regarded as the most scientific and objective method for assessing skin barrier function and is widely used in clinical practice and dermatological research worldwide.

Although conventional TEWL measurement technologies have long served as the standard, they present several structural limitations in real-world clinical and practical applications:

• High sensitivity to external environmental changes, requiring strictly controlled temperature and humidity conditions
• Measurement times of 10-20 seconds or longer, limiting repeated measurements and real-time use
• Low measurement reproducibility, with strong dependence on the operator and surrounding environment
• Results provided as a single numerical value, failing to reflect the spatial distribution of skin barrier function

Due to these limitations, TEWL measurements have largely been confined to controlled research settings, and fundamental improvements have been required for broader clinical and everyday use.

Lumihume fundamentally overcomes the limitations of conventional TEWL measurement by combining advanced nanophotonic materials with sensor designs that incorporate the fluid-dynamic characteristics of transepidermal water loss.
By rapidly detecting optically amplified humidity signals and minimizing the influence of external environmental variations through structural design, Lumihume enables TEWL measurements that are faster, more accurate, and highly reproducible.

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  Stability

  Stable measurement performance with minimal sensitivity to external environmental conditions

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  Speed

  Ultrafast measurement within 5 seconds, enabling real-time skin barrier diagnostics

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  Reliability

  High measurement reproducibility, enhancing clinical and research reliability

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  Visualization

  Visualization of two-dimensional data, allowing analysis of the spatial distribution of skin barrier function

Lumihume’s technology moves beyond conventional, number-based TEWL measurements, introducing a new diagnostic paradigm that enables intuitive understanding and interpretation of skin barrier health.